Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.43 |
| ▸ | HTR2B | P41595 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10955829 | 0.87 | MAOA (0.50) | MAOAMAOBSLC6A4MAPTDRD1 | |
| SCHEMBL18256785 | 0.80 | SLC6A4 (0.40) | HTR2AMAOAMAOBSLC6A4SLC6A2 | |
| SCHEMBL11451950 | 0.74 | CYP3A4 (0.60) | MAOAMAOBSLC6A4DRD1DRD5 | |
| SCHEMBL18034982 | 0.74 | SLC6A4 (0.62) | SLC6A4DRD1DRD5SLC6A2SLC6A3 | |
| SCHEMBL15778994 | 0.73 | SLC6A2 (0.40) | HTR2CHTR2BHTR2ASLC6A4DRD1 | |
| SCHEMBL18034964 | 0.72 | SLC6A4 (0.63) | SLC6A4DRD1DRD5SLC6A2SLC6A3 | |
| SCHEMBL29596997 | 0.72 | DRD1 (0.47) | MAOASLC6A4MAPTMAPK1DRD1 | |
| SCHEMBL1096839 | 0.71 | HTR2C (0.58) | HTR2CHTR2BHTR2AMAOAMAOB | |
| SCHEMBL1096838 | 0.71 | HTR2C (0.58) | HTR2CHTR2BHTR2AMAOAMAOB | |
| SCHEMBL1901665 | 0.71 | HTR2C (0.58) | HTR2CHTR2BHTR2AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240363-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098806-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |