Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29516502 | 1.00 | CYP4F2 (0.45) | CYP4F2CYP4A11TP53DRD3LMNA | |
| SCHEMBL24239391 | 1.00 | CYP4F2 (0.45) | CYP4F2CYP4A11TP53DRD3LMNA | |
| SCHEMBL24229002 | 1.00 | CYP4F2 (0.45) | CYP4F2CYP4A11TP53DRD3LMNA | |
| SCHEMBL24228942 | 1.00 | CYP4F2 (0.45) | CYP4F2CYP4A11TP53DRD3LMNA | |
| SCHEMBL545604 | 1.00 | CYP4F2 (0.45) | CYP4F2CYP4A11TP53DRD3LMNA | |
| SCHEMBL537418 | 0.86 | ROCK2 (0.51) | CYP4F2CYP4A11TP53LMNAMAOB | |
| SCHEMBL1519508 | 0.83 | ROCK2 (0.51) | CYP4F2CYP4A11TP53LMNAROCK2 | |
| SCHEMBL1519430 | 0.83 | MALT1 (0.42) | CYP4F2CYP4A11TP53LMNAMAOB | |
| SCHEMBL1519562 | 0.83 | ROCK2 (0.51) | CYP4F2CYP4A11TP53LMNAMAOB | |
| SCHEMBL27927241 | 0.83 | TDP1 (0.55) | CYP4F2CYP4A11TP53LMNAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348465-A | Chiral synthesis of fused bicyclic RAF inhibitors | 爵士制药爱尔兰有限公司 | 2023-06-27 | — | — | CN | claimed |
| EP-4188923-A1 | CHIRAL SYNTHESIS OF FUSED BICYCLIC RAF INHIBITORS | Jazz Pharmaceuticals Ireland Limited (IE) | 2023-06-07 | — | — | EP | claimed |
| CN-114921508-B | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-10-11 | — | — | CN | claimed |
| CN-114921508-A | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-08-19 | — | — | CN | claimed |
| WO-2022023450-A1 | CHIRAL SYNTHESIS OF FUSED BICYCLIC RAF INHIBITORS | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2022-02-03 | — | — | WO | claimed |
| CN-116348465-A | Chiral synthesis of fused bicyclic RAF inhibitors | 爵士制药爱尔兰有限公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-4188923-A1 | CHIRAL SYNTHESIS OF FUSED BICYCLIC RAF INHIBITORS | Jazz Pharmaceuticals Ireland Limited (IE) | 2023-06-07 | — | — | EP | disclosed |
| CN-114921508-B | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-114921508-B | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-114921508-B | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-114921508-A | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-114921508-A | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-114921508-A | Biocatalytic preparation method of (R) -6-hydroxy chroman-3-carboxylic acid | 常熟药明康德新药开发有限公司 | 2022-08-19 | — | — | CN | disclosed |
| WO-2022023450-A1 | CHIRAL SYNTHESIS OF FUSED BICYCLIC RAF INHIBITORS | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2022-02-03 | — | — | WO | disclosed |