SCHEMBL29516993

SCHEMBL29516993

Cc1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)NC(C)C[S+]=O

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 10/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.32
GAA P10253 1/20 0.32
ALOX12 P18054 1/20 0.32
HSD17B10 Q99714 1/20 0.32
HDAC6 Q9UBN7 8/20 0.31
ITGB1 P05556 1/20 0.30
ITGA4 P13612 1/20 0.30
HDAC1 Q13547 2/20 0.30
IL2 P60568 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29001060 0.92 HDAC4 (0.32) HDAC4CA1CA2KDM4EALDH1A1
SCHEMBL14641786 0.88 MLYCD (0.36) HDAC4CA1CA2KDM4EALDH1A1
SCHEMBL13769684 0.87 HDAC4 (0.32) HDAC4CA1CA2KDM4EALDH1A1
SCHEMBL2992226 0.87 HDAC4 (0.32) HDAC4CA1CA2KDM4EALDH1A1
SCHEMBL28908172 0.85 CA1 (0.35) CA1CA2KDM4EALDH1A1IL2
SCHEMBL28387913 0.85 CA1 (0.34) CA1CA2ITGB1ITGA4
SCHEMBL12846270 0.85 S1PR1 (0.33) CA1CA2ITGB1ITGA4
SCHEMBL740200 0.84 CA1 (0.40) CA1CA2KDM4EHDAC6HDAC1
SCHEMBL30631644 0.84 CA1 (0.40) CA1CA2KDM4EHDAC6HDAC1
SCHEMBL738508 0.84 CA1 (0.36) HDAC4CA1CA2KDM4EHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110198942-B Fused heterocyclic compound and composition containing the same 住友化学株式会社 2022-04-15 CN disclosed
CN-110914264-B Heterocyclic compound and harmful arthropod control agent containing same 住友化学株式会社 2022-02-11 CN disclosed