Akuammicine

Akuammicine

SCHEMBL29517606

C/C=C1/CN2CC[C@]34C(=C(C(=O)OC)[C@H]1C[C@H]23)Nc1ccccc14

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.69
KMT2A Q03164 1/20 0.69
TDP1 Q9NUW8 1/20 0.69
OPRK1 P41145 7/20 0.60
STK17B O94768 1/20 0.46
ALDH1A1 P00352 4/20 0.45
KDM4E B2RXH2 2/20 0.45
HSD17B10 Q99714 2/20 0.45
TSHR P16473 1/20 0.45
GAA P10253 1/20 0.45
HTT P42858 1/20 0.45
OPRM1 P35372 8/20 0.43
HTR1A P08908 2/20 0.43
OPRD1 P41143 4/20 0.41
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Akuammicine SCHEMBL23675922 1.00 MEN1 (0.69) MEN1KMT2ATDP1OPRK1STK17B
Akuammicine SCHEMBL2685206 1.00 MEN1 (0.69) MEN1KMT2ATDP1OPRK1STK17B
Akuammicine SCHEMBL26667911 1.00 MEN1 (0.69) MEN1KMT2ATDP1OPRK1STK17B
Vinervine SCHEMBL30046744 0.90 MEN1 (0.74) MEN1KMT2ATDP1OPRK1STK17B
SCHEMBL26668918 0.89 MEN1 (0.55) MEN1KMT2ATDP1OPRK1STK17B
Sewarine SCHEMBL30047246 0.88 MEN1 (0.54) MEN1KMT2ATDP1OPRK1STK17B
Sewarine SCHEMBL26668717 0.88 MEN1 (0.54) MEN1KMT2ATDP1OPRK1STK17B
SCHEMBL26667892 0.87 MEN1 (0.53) MEN1KMT2ATDP1OPRK1STK17B
SCHEMBL26668570 0.87 MEN1 (0.53) MEN1KMT2ATDP1OPRK1STK17B
SCHEMBL26668915 0.87 MEN1 (0.53) MEN1KMT2ATDP1OPRK1STK17B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132145-A1 METHODS OF PREPARING ISOMERS, ANALOGS, AND SYNTHETIC DERIVATIVES FROM AKUAMMA SEEDS MITCHELL HAYWOOD MAX (US) 2026-05-14 US disclosed
CN-114245826-A Method for producing strictoside and monoterpene indole alkaloid 丹麦科技大学 2022-03-25 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132145-A1 METHODS OF PREPARING ISOMERS, ANALOGS, AND SYNTHETIC DERIVATIVES FROM AKUAMMA SEEDS AAK1, AURKA, KMO MEN1 4856/4885KMT2A 301/4885TDP1 2639/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.