Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 3/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866130 | 1.00 | TSHR (0.46) | TSHRSMN1; SMN2KDM4EGRM5DEGS1 | |
| SCHEMBL1428235 | 0.83 | L3MBTL1 (0.48) | TSHRSMN1; SMN2KDM4EGRM5DEGS1 | |
| SCHEMBL29563708 | 0.83 | HSD17B10 (0.57) | TSHRSMN1; SMN2KDM4EFFAR2RAB9A | |
| SCHEMBL30518834 | 0.83 | L3MBTL1 (0.48) | TSHRSMN1; SMN2KDM4EGRM5DEGS1 | |
| SCHEMBL28550716 | 0.83 | TDP1 (0.47) | TSHRSMN1; SMN2KDM4EGRM5DEGS1 | |
| SCHEMBL18629790 | 0.83 | HSD17B10 (0.57) | TSHRSMN1; SMN2KDM4EFFAR2RAB9A | |
| SCHEMBL1144049 | 0.83 | SMN1; SMN2 (0.45) | TSHRSMN1; SMN2KDM4EGRM5DEGS1 | |
| Hydrochloric Acid SCHEMBL2186490 | 0.81 | L3MBTL1 (0.47) | TSHRSMN1; SMN2KDM4EGRM5DEGS1 | |
| SCHEMBL15004187 | 0.81 | TSHR (0.69) | TSHRSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL3403751 | 0.80 | TSHR (0.68) | TSHRSMN1; SMN2KDM4EDEGS1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118894856-A | Pyrazole-containing polycyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-118894855-A | Pyrazole-containing polycyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-114222746-B | Pyrazole-containing polycyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-112778311-B | Nitrogen-containing fused ring derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-112409331-B | Heterocyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-02-20 | — | — | CN | disclosed |
| WO-2023118092-A1 | PYRAZOLO[1,5-A]PYRIDO[3,2-E]PYRIMIDINES AND PYRAZOLO[1,5-A][1,3]THIAZOLO[5,4-E]PYRIMIDINES AS P2X3 INHIBITORS FOR THE TREATMENT OF NEUROGENIC DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-06-29 | — | — | WO | disclosed |
| CN-111527090-B | Pyrazolo-pyrrolo-pyrimidine-dione derivatives as P2X3 inhibitors | 拜耳公司 | 2023-05-26 | — | — | CN | disclosed |
| WO-2022258007-A1 | SALT AND CRYSTAL FORM OF PYRAZOLE-CONTAINING POLYCYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2022-12-15 | — | — | WO | disclosed |
| CN-115448875-A | Preparation method of polycyclic derivative containing pyrazole | 上海翰森生物医药科技有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-115448922-A | Free base crystal form containing pyrazole polycyclic derivative and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-114222746-A | Pyrazole-containing polycyclic derivative inhibitor, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-03-22 | — | — | CN | disclosed |