Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 7/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037804 | 1.00 | KMO (0.55) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL17678345 | 0.84 | KMO (0.59) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL30381343 | 0.81 | KMO (0.59) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL6181444 | 0.81 | KMO (0.59) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL3980684 | 0.81 | HTR2A (0.47) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL2318217 | 0.80 | KMO (0.48) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL30385717 | 0.80 | KMO (0.48) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL6427370 | 0.80 | KMO (0.48) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL30817517 | 0.80 | KMO (0.60) | KMOHTR2AHTR2CHTR2BIRAK4 | |
| SCHEMBL23631639 | 0.78 | KMO (0.59) | KMOHTR2AHTR2CHTR2BIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |