Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065409 | 0.79 | POLB (0.44) | KDM4EHSD17B10NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17969377 | 0.78 | KDM4E (0.35) | KDM4EHSD17B10NPC1TP53RAB9A | |
| SCHEMBL29520372 | 0.76 | NPC1 (0.42) | KDM4EHSD17B10NPC1TP53RAB9A | |
| SCHEMBL6259455 | 0.76 | NPC1 (0.42) | KDM4EHSD17B10NPC1TP53RAB9A | |
| SCHEMBL30638944 | 0.76 | HTT (0.56) | KDM4ENPC1TP53ALDH1A1HPGD | |
| SCHEMBL1192213 | 0.76 | LMNA (0.47) | KDM4EHSD17B10NPC1TP53RAB9A | |
| SCHEMBL5252051 | 0.76 | NPC1 (0.42) | KDM4EHSD17B10NPC1TP53RAB9A | |
| SCHEMBL22095110 | 0.75 | TSHR (0.51) | KDM4ENPC1TP53RAB9AALDH1A1 | |
| SCHEMBL18543756 | 0.74 | NPC1 (0.38) | KDM4EHSD17B10NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25346913 | 0.74 | IRAK4 (0.36) | KDM4ENPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |