Sugi Predict

Sugi Predict / Compounds / SCHEMBL29520597

SCHEMBL29520597

SCHEMBL29520597

CN1CCN(c2ccc(N)cc2F)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.66
▸ MAPT P10636 7/20 0.66
▸ GFER P55789 3/20 0.66
▸ MAPK1 P28482 2/20 0.66
▸ LMNA P02545 1/20 0.66
▸ TDP1 Q9NUW8 1/20 0.66
▸ KDM4E B2RXH2 5/20 0.65
▸ RAD52 P43351 2/20 0.65
▸ L3MBTL1 Q9Y468 2/20 0.60
▸ GAA P10253 4/20 0.52
▸ ADRA2C P18825 3/20 0.52
▸ PTK2B Q14289 3/20 0.52
▸ KMT2A Q03164 2/20 0.52
▸ ESR2 Q92731 1/20 0.52
▸ POLB P06746 2/20 0.51
▸ HTT P42858 2/20 0.49
▸ RECQL P46063 1/20 0.49
▸ HSD17B10 Q99714 1/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ THRB P10828 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL159044 1.00 ALDH1A1 (0.66) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL880495 0.94 ALDH1A1 (0.59) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL17265648 0.91 ALDH1A1 (0.77) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL9300032 0.86 MAPT (0.60) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL23126590 0.85 MAPT (0.54) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL10036448 0.85 ALDH1A1 (0.54) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL10036378 0.85 ALDH1A1 (0.50) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL10128072 0.85 ALDH1A1 (0.54) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL7038110 0.83 ALDH1A1 (0.67) ALDH1A1MAPTGFERMAPK1LMNA
SCHEMBL3442442 0.83 ALDH1A1 (0.67) ALDH1A1MAPTGFERMAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109206375-B 5-position ring-substituted 2, 4-diaminopyrimidine compound with phenylglycinol structure, and preparation and application thereof 中国科学院上海药物研究所 2023-02-17 — — CN claimed
CN-117886824-B 2, 3-Dihydropyrimido [4,5-d ] pyrimidine-4 (1H) -ketone derivative, preparation method and application thereof 四川大学华西医院 2026-05-15 — — CN disclosed
US-20250382277-A1 SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF UNIV ARIZONA (US) 2025-12-18 — — US disclosed
CN-119431239-A Compounds, pharmaceutical compositions, kits and uses thereof 密执安大学评议会 2025-02-14 — — CN disclosed
CN-113710241-B Substituted bicyclic and tetracyclic quinones and related methods of use 密执安大学评议会 2024-11-15 — — CN disclosed
CN-118176195-A Pyrazolo [3,4-d ] pyrimidine-3-ketone compound and medical application thereof 正大天晴药业集团股份有限公司 2024-06-11 — — CN disclosed
CN-118159533-A Heterocyclic compounds and their use 艾森医药有限公司 2024-06-07 — — CN disclosed
CN-117886824-A 2, 3-dihydropyrimido [4,5-d ] pyrimidine-4 (1H) -ketone derivative, preparation method and application thereof 四川大学华西医院 2024-04-16 — — CN disclosed
CN-112739701-B Fused pyrimidine skeleton sulfonamide derivative with inhibition effect of epidermal growth factor receptor mutation 韩美药品株式会社 2024-02-13 — — CN disclosed
CN-111566100-B Pyrimidine compound, preparation method and medical application thereof 恩瑞生物医药科技（上海）有限公司 2023-10-27 — — CN disclosed
CN-113614087-B WEE1 inhibitor and preparation and application thereof 首药控股(北京)股份有限公司 2023-06-02 — — CN disclosed
CN-116199636-A 2, 4-disubstituted pyrimidine derivative of targeted tumor immunity kinase, preparation method and application thereof 杭州医学院 2023-06-02 — — CN disclosed
CN-111825605-B Aryl ketone amide compound and preparation method and application thereof 中国科学院上海药物研究所 2023-03-31 — — CN disclosed
EP-4153576-A1 NOTCH INHIBITORS AND USES THEREOF StemSynergy Therapeutics, Inc. (US) 2023-03-29 — — EP disclosed
CN-115836056-A NOTCH inhibitors and uses thereof STEMSYNERGY疗法有限责任公司 2023-03-21 — — CN disclosed
CN-109206375-B 5-position ring-substituted 2, 4-diaminopyrimidine compound with phenylglycinol structure, and preparation and application thereof 中国科学院上海药物研究所 2023-02-17 — — CN disclosed
US-20220194960-A1 WEE1 INHIBITOR AND PREPARATION AND USE THEREOF Shouyao Holdings (beijing) Co., Ltd. (CN) 2022-06-23 — — US disclosed
WO-2022126133-A1 ALK-5 INHIBITORS AND USES THEREOF SUMITOMO PHARMA ONCOLOGY,INC. (US) 2022-06-16 — — WO disclosed
WO-2022063140-A1 PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) 2022-03-31 — — WO disclosed
WO-2022063106-A1 INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS BEIGENE, LTD. (KY) 2022-03-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250382277-A1 SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF CLK2, CLK3, CLK1 ALDH1A1 4568/4885MAPT 1251/4885GFER 4733/4885
US-20220194960-A1 WEE1 INHIBITOR AND PREPARATION AND USE THEREOF WEE1, WEE2, RCE1 ALDH1A1 3670/4885MAPT 25/4885GFER 1584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.