Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.53 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.52 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GLI1 | P08151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24277517 | 1.00 | HDAC8 (0.61) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL24277516 | 1.00 | HDAC8 (0.61) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL15399610 | 0.88 | HDAC8 (0.61) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL3690574 | 0.87 | HDAC8 (0.60) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL26980197 | 0.87 | HDAC8 (0.60) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL26305770 | 0.86 | HDAC8 (0.59) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL24277699 | 0.85 | HDAC8 (0.45) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL24277700 | 0.85 | HDAC8 (0.45) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL28976207 | 0.85 | MAPT (0.58) | HDAC8HSD17B10MAPTHIF1AKDM4E | |
| SCHEMBL7559848 | 0.85 | HDAC8 (0.64) | HDAC8HSD17B10MAPTHIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4211114-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | The Regents of the University of California (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022056068-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | THE REGENTS OF THE UNIVERSITY OFCALIFORNIA (US) | 2022-03-17 | — | — | WO | disclosed |