Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 5/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 7/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCND3 | P30281 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CCND2 | P30279 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10187855 | 0.72 | BCL6 (0.53) | WEE1SRCCDK4CYP1A2CYP3A4 | |
| SCHEMBL2955963 | 0.69 | TNK2 (0.70) | TNK2 | |
| SCHEMBL4701225 | 0.69 | TNK2 (0.49) | SRCTNK2CYP3A4MEN1TSHR | |
| SCHEMBL31689813 | 0.68 | PKMYT1 (0.60) | WEE1CYP3A4CYP2C9CYP2D6CDK1 | |
| SCHEMBL31737850 | 0.67 | MERTK (0.55) | WEE1MERTKCDK4CCND3CYP1A2 | |
| SCHEMBL23853930 | 0.66 | GAA (0.53) | WEE1SRCGSK3AGSK3BCDK1 | |
| SCHEMBL10187876 | 0.65 | CDK2 (0.53) | SRCCDK4CCND3CYP1A2CYP3A4 | |
| SCHEMBL20953571 | 0.65 | RAB9A (0.59) | SRCCDK4GSK3AGSK3BCCND1 | |
| SCHEMBL28743981 | 0.65 | JAK2 (0.56) | SRCCDK4CCND3CYP1A2CYP3A4 | |
| SCHEMBL29695644 | 0.65 | CDK2 (0.64) | SRCCDK4CCND3GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763624-B2 | Substituted pyrazolo[3,4-d]pyrimidines as ACK-1 and LCK inhibitors | AMGEN INC. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20070072851-A1 | Pyrazolopyridine and pyrazolopyrimidine compounds | AMGEN INC. (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072851-A1 | Pyrazolopyridine and pyrazolopyrimidine compounds | LCK, MAP4K5, TPMT | WEE1 771/4885SRC 64/4885TNK2 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.