Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 known ✓ | P47869 | 8/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 3/20 | 0.48 |
| ▸ | GABRD | O14764 | 3/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.48 |
| ▸ | GABRE | P78334 | 3/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromazepam SCHEMBL43933 | 1.00 | ADRA1A (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL29366892 | 1.00 | ADRA1A (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL29382152 | 1.00 | ADRA1A (1.00) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL17225092 | 0.85 | ADRA1A (0.73) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| Bromazepam SCHEMBL8414304 | 0.85 | ADRA1A (0.73) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7377690 | 0.85 | ADRA1A (0.74) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7374778 | 0.85 | ADRA1A (0.74) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7951942 | 0.85 | ADRA1A (0.74) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL14215423 | 0.85 | ADRA1A (0.74) | ADRA1AGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7477766 | 0.84 | ADRA1A (0.72) | ADRA1AGABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116253761-A | Method for preparing Rate Malun O-phosphoryl intermediate | 宜昌人福药业有限责任公司 | 2023-06-13 | — | — | CN | claimed |
| CN-110585165-B | Abuse resistant capsules | R·P·谢勒技术有限公司 | 2022-08-12 | — | — | CN | claimed |
| EP-4536404-A1 | METHODS AND DEVICES FOR GENERATING CORE-SHELL DROPLETS AND PARTICLES | The Trustees of Princeton University (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119355151-A | Isomer detection method of key intermediate of Rayleigh Malun | 浙江雅辰药物科技股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119355151-A | Isomer detection method of key intermediate of Rayleigh Malun | 浙江雅辰药物科技股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-108743549-B | Self-regulating release of active pharmaceutical ingredient | 阿库拉制药公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-117761193-A | Analysis and detection method for rimazolam intermediate | 上海药坦药物研究开发有限公司 | 2024-03-26 | — | — | CN | disclosed |
| WO-2023239688-A1 | METHODS AND DEVICES FOR GENERATING CORE-SHELL DROPLETS AND PARTICLES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2023-12-14 | — | — | WO | disclosed |
| CN-115626913-B | Method for preparing key intermediate of Rayleigh Malun | 上海再启生物技术有限公司 | 2023-12-01 | — | — | CN | disclosed |
| EP-4228597-A1 | MODIFIED RELEASE SOFTGEL CAPSULES | R.P. Scherer Technologies, LLC (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4228608-A1 | CONTROLLED RELEASE FILL COMPOSITIONS AND CAPSULES CONTAINING SAME | R.P. Scherer Technologies, LLC (US) | 2023-08-23 | — | — | EP | disclosed |
| CN-116322655-A | Soft gel capsule for regulating release | R·P·谢勒技术有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116253761-A | Method for preparing Rate Malun O-phosphoryl intermediate | 宜昌人福药业有限责任公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-116253761-A | Method for preparing Rate Malun O-phosphoryl intermediate | 宜昌人福药业有限责任公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-115626913-A | Method for preparing key intermediate of remimazolam | 上海再启生物技术有限公司 | 2023-01-20 | — | — | CN | disclosed |
| EP-4114374-A1 | SYSTEM AND METHOD FOR AEROSOL PARTICLE PRODUCTION OF SUBMICRON AND NANO STRUCTURED MATERIALS | The Trustees of Princeton University (US) | 2023-01-11 | — | — | EP | disclosed |
| CN-110585165-B | Abuse resistant capsules | R·P·谢勒技术有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2022081848-A1 | CONTROLLED RELEASE FILL COMPOSITIONS AND CAPSULES CONTAINING SAME | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022082222-A1 | MODIFIED RELEASE SOFTGEL CAPSULES | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2022-04-21 | — | — | WO | disclosed |
| CN-114014839-A | Method for preparing key intermediate of remimazolam | 上海再启生物技术有限公司 | 2022-02-08 | — | — | CN | disclosed |