SCHEMBL29522752

SCHEMBL29522752

N#CCNC(=O)c1cccc(-c2csc3cnc(Nc4ccc(CN5CCOCC5)cc4)nc23)c1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTK2 Q05397 16/20 0.59
JAK2 O60674 4/20 0.58
JAK3 P52333 4/20 0.58
LCK P06239 1/20 0.48
FYN P06241 1/20 0.48
FES P07332 1/20 0.48
RET P07949 1/20 0.48
ROS1 P08922 1/20 0.48
CDK4 P11802 1/20 0.48
SRC P12931 1/20 0.48
JAK1 P23458 1/20 0.48
TYK2 P29597 1/20 0.48
EPHB1 P54762 1/20 0.48
CSNK2A1 P68400 1/20 0.48
DDR1 Q08345 1/20 0.48
KCNH2 Q12809 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1674214 1.00 PTK2 (0.59) PTK2JAK2JAK3LCKFYN
SCHEMBL29523554 0.91 JAK2 (0.69) PTK2JAK2JAK3LCKFYN
SCHEMBL1674021 0.91 JAK2 (0.69) PTK2JAK2JAK3LCKFYN
SCHEMBL12804509 0.91 PTK2 (0.60) PTK2JAK3LCKFYNFES
SCHEMBL1674030 0.84 PTK2 (0.67) PTK2JAK2JAK3LCKFYN
SCHEMBL29799032 0.83 JAK2 (0.67) PTK2JAK2JAK3LCKFYN
SCHEMBL1674472 0.81 PTK2 (0.79) PTK2JAK2JAK3LCKFYN
SCHEMBL1674069 0.81 JAK2 (0.69) PTK2JAK2JAK3JAK1TYK2
SCHEMBL29523759 0.81 JAK2 (0.69) PTK2JAK2JAK3JAK1TYK2
SCHEMBL12801797 0.81 PTK2 (0.68) PTK2JAK2JAK3LCKFYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735462-A1 COMPOUNDS AND USES THEREFOR GLYCOSYNNOVATIONS PTY LTD (AU) 2026-05-06 EP disclosed
EP-4735463-A1 COMPOUNDS AND USES THEREFOR GLYCOSYNNOVATIONS PTY LTD (AU) 2026-05-06 EP disclosed
EP-3980400-B1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS UNIV EMORY (US) 2025-08-06 EP disclosed
EP-4565577-A1 INHIBITORS AND USES THEREFOR Macquarie University (AU) 2025-06-11 EP disclosed
EP-4556010-A2 JAK INHIBITORS FOR USE IN THE PREVENTION OR TREATMENT OF A VIRAL DISEASE CAUSED BY A CORONAVIRIDAE Emory University (US) 2025-05-21 EP disclosed
WO-2025000059-A1 COMPOUNDS AND USES THEREFOR Glycosynnovations Pty Ltd (AU) 2025-01-02 WO disclosed
WO-2025000061-A1 COMPOUNDS AND USES THEREFOR Glycosynnovations Pty Ltd (AU) 2025-01-02 WO disclosed
CN-117881403-A Thionucleosides as antiviral agents 爱莫里大学 2024-04-12 CN disclosed
CN-117858711-A Nucleoside and nucleotide analogs as antiviral agents 爱莫里大学 2024-04-09 CN disclosed
CN-117769427-A Modified nucleosides and nucleotide analogues as antiviral agents for coronaviruses and other viruses 埃默里大学 2024-03-26 CN disclosed
EP-4319762-A2 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS Emory University (US) 2024-02-14 EP disclosed
EP-4319763-A2 MODIFIED NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS FOR CORONA AND OTHER VIRUSES Emory University (US) 2024-02-14 EP disclosed
EP-4319764-A2 THIONUCLEOSIDES AS ANTIVIRAL AGENTS Emory University (US) 2024-02-14 EP disclosed
WO-2024026540-A1 INHIBITORS AND USES THEREFOR MACQUARIE UNIVERSITY (AU) 2024-02-08 WO disclosed
WO-2022217155-A2 THIONUCLEOSIDES AS ANTIVIRAL AGENTS EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
WO-2022217153-A2 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
WO-2022217154-A2 MODIFIED NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS FOR CORONA AND OTHER VIRUSES EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
EP-3980400-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS Emory University (US) 2022-04-13 EP disclosed