SCHEMBL29523554

SCHEMBL29523554

N#CCNC(=O)c1cccc(-c2csc3cnc(Nc4ccc(N5CCOCC5)cc4)nc23)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 5/20 0.69
PTK2 Q05397 15/20 0.68
JAK3 P52333 4/20 0.59
JAK1 P23458 2/20 0.56
TYK2 P29597 2/20 0.56
BMPR1B O00238 1/20 0.56
PLK4 O00444 1/20 0.56
CIT O14578 1/20 0.56
GAK O14976 1/20 0.56
OPA1 O60313 1/20 0.56
ROCK2 O75116 1/20 0.56
STK16 O75716 1/20 0.56
PRKD3 O94806 1/20 0.56
CSNK2A2 P19784 1/20 0.56
CDK2 P24941 1/20 0.56
MARK3 P27448 1/20 0.56
BMPR1A P36894 1/20 0.56
TGFBR1 P36897 1/20 0.56
STAT3 P40763 1/20 0.56
STAT5A P42229 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1674021 1.00 JAK2 (0.69) JAK2PTK2JAK3JAK1TYK2
SCHEMBL29799032 0.93 JAK2 (0.67) JAK2PTK2JAK3JAK1TYK2
SCHEMBL1674069 0.91 JAK2 (0.69) JAK2PTK2JAK3JAK1TYK2
SCHEMBL29523759 0.91 JAK2 (0.69) JAK2PTK2JAK3JAK1TYK2
SCHEMBL1674214 0.91 PTK2 (0.59) JAK2PTK2JAK3JAK1TYK2
SCHEMBL29522752 0.91 PTK2 (0.59) JAK2PTK2JAK3JAK1TYK2
SCHEMBL12801797 0.90 PTK2 (0.68) JAK2PTK2JAK3JAK1TYK2
SCHEMBL29530503 0.87 PTK2 (0.69) JAK2PTK2JAK3JAK1TYK2
SCHEMBL1674029 0.87 PTK2 (0.69) JAK2PTK2JAK3JAK1TYK2
SCHEMBL22022743 0.87 PTK2 (0.79) JAK2PTK2JAK3JAK1TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735463-A1 COMPOUNDS AND USES THEREFOR GLYCOSYNNOVATIONS PTY LTD (AU) 2026-05-06 EP disclosed
EP-4735462-A1 COMPOUNDS AND USES THEREFOR GLYCOSYNNOVATIONS PTY LTD (AU) 2026-05-06 EP disclosed
EP-4565577-A1 INHIBITORS AND USES THEREFOR Macquarie University (AU) 2025-06-11 EP disclosed
WO-2025000059-A1 COMPOUNDS AND USES THEREFOR Glycosynnovations Pty Ltd (AU) 2025-01-02 WO disclosed
WO-2025000061-A1 COMPOUNDS AND USES THEREFOR Glycosynnovations Pty Ltd (AU) 2025-01-02 WO disclosed
CN-117881403-A Thionucleosides as antiviral agents 爱莫里大学 2024-04-12 CN disclosed
CN-117858711-A Nucleoside and nucleotide analogs as antiviral agents 爱莫里大学 2024-04-09 CN disclosed
CN-117769427-A Modified nucleosides and nucleotide analogues as antiviral agents for coronaviruses and other viruses 埃默里大学 2024-03-26 CN disclosed
EP-4319763-A2 MODIFIED NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS FOR CORONA AND OTHER VIRUSES Emory University (US) 2024-02-14 EP disclosed
EP-4319762-A2 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS Emory University (US) 2024-02-14 EP disclosed
EP-4319764-A2 THIONUCLEOSIDES AS ANTIVIRAL AGENTS Emory University (US) 2024-02-14 EP disclosed
WO-2024026540-A1 INHIBITORS AND USES THEREFOR MACQUARIE UNIVERSITY (AU) 2024-02-08 WO disclosed
WO-2022217155-A2 THIONUCLEOSIDES AS ANTIVIRAL AGENTS EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
WO-2022217153-A2 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
WO-2022217154-A2 MODIFIED NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS FOR CORONA AND OTHER VIRUSES EMORY UNIVERSITY (US) 2022-10-13 WO disclosed
EP-3980400-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS Emory University (US) 2022-04-13 EP disclosed