Human Neuropeptide Y

SCHEMBL29523348

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	CALCR	P30988	4/20	0.72

▸	NPY2R	P49146	10/20	0.69

▸	NPY4R	P50391	8/20	0.69

▸	NPY5R	Q15761	8/20	0.69

▸	NPY1R	P25929	8/20	0.69

▸	CRHR1	P34998	1/20	0.68

▸	CRHR2	Q13324	1/20	0.68

▸	GLP1R	P43220	3/20	0.64

▸	GCGR	P47871	2/20	0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29496288	0.95	NPY2R (0.74)	CALCRNPY2RNPY4RNPY5RNPY1R
Human Neuropeptide Y SCHEMBL29780330	0.94	NPY2R (0.79)	CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL29571016	0.94	NPY2R (0.70)	CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL29496391	0.94	NPY2R (0.72)	CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL29440046	0.92	CRHR1 (0.77)	CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL29526997	0.92	NPY2R (0.72)	CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL13248707	0.92	NPY2R (0.80)	CALCRNPY2RNPY4RNPY5RNPY1R
Neuropeptide-Y SCHEMBL3051623	0.91	NPY2R (0.82)	CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL29570760	0.91	NPY2R (0.69)	CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL29975560	0.91	NPY2R (0.69)	CALCRNPY2RNPY4RNPY5RNPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-12551533-B2	Intranasal neuropeptides for use in stress-related impairments	NEW YORK MEDICAL COLLEGE (US)	2026-02-17	—	—	US	disclosed
US-20220143147-A1	INTRANASAL NEUROPEPTIDES FOR USE IN STRESS-RELATED IMPAIRMENTS	NEW YORK MEDICAL COLLEGE	2022-05-12	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-12551533-B2	Intranasal neuropeptides for use in stress-related impairments	NPY5R, NPY1R, NPY2R	CALCR 1093/4885NPY2R 3/4885NPY4R 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.