Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22773696 | 1.00 | HTT (0.36) | HTTGRM5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19152982 | 0.79 | TSHR (0.40) | HTTGRM5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL30646095 | 0.78 | GRM5 (0.42) | HTTGRM5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18238059 | 0.74 | TSHR (0.34) | HTTGRM5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL9014728 | 0.71 | NPC1 (0.37) | ALDH1A1NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL29649268 | 0.70 | HTT (0.41) | HTTGRM5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1988087 | 0.70 | HTT (0.41) | HTTGRM5ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22787128 | 0.69 | LTB4R (0.38) | SMN1; SMN2KDM4EKMT2ATSHRMEN1 | |
| SCHEMBL29526263 | 0.68 | GRM5 (0.51) | GRM5ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17361975 | 0.68 | GRM5 (0.51) | GRM5ALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983406-A1 | UNSATURATED HETEROCYCLOALKYL AND HETEROAROMATIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | Ontario Institute for Cancer Research (OICR) (CA) | 2022-04-20 | — | — | EP | disclosed |