Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL2963342 | 0.99 | TDP1 (0.60) | TDP1HSD17B10SMN1; SMN2USP2 | |
| Malic Acid SCHEMBL2959967 | 0.93 | TDP1 (0.51) | TDP1HSD17B10SMN1; SMN2USP2 | |
| Malic Acid SCHEMBL2953325 | 0.90 | TDP1 (0.43) | TDP1SMN1; SMN2 | |
| Malic Acid SCHEMBL2956745 | 0.88 | TDP1 (0.44) | TDP1SMN1; SMN2 | |
| Malic Acid SCHEMBL2957315 | 0.87 | SMN1; SMN2 (0.41) | TDP1SMN1; SMN2 | |
| Cadaverine Tartrate SCHEMBL2953437 | 0.87 | TDP1 (0.66) | TDP1HSD17B10USP2 | |
| Succinic Acid SCHEMBL2962575 | 0.87 | TDP1 (0.66) | TDP1HSD17B10USP2 | |
| Malic Acid SCHEMBL2955588 | 0.85 | SMN1; SMN2 (0.42) | TDP1SMN1; SMN2 | |
| Malic Acid SCHEMBL2958837 | 0.85 | SMN1; SMN2 (0.44) | TDP1HSD17B10SMN1; SMN2 | |
| Succinic Acid SCHEMBL2949135 | 0.85 | TDP1 (0.68) | TDP1HSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7766978-B2 | Acidic hair dyeing method | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20090100609-A1 | ACIDIC HAIR DYE COMPOSITION | KOKYU ALCOHOL KOGYO CO., LTD. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090100609-A1 | ACIDIC HAIR DYE COMPOSITION | H1-0, MRM1, H1-4 | TDP1 1628/4885HSD17B10 182/4885SMN1; SMN2 3802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.