Sugi Predict

Sugi Predict / Targets / MRM1

MRM1

rRNA methyltransferase 1, mitochondrial · Q6IN84 · MRM1 on Sugi Atlas →

0 patent compounds predicted against MRM1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to MRM1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF) PHASE1/PHASE2COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Collection of Samples of Bone Marrow Aspiration From Patients With Myelodysplastic Syndrome nanACTIVE_NOT_RECRUITING
Choroid Plexus Dysfunction in Neurological Diseases nanRECRUITING
The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling nanACTIVE_NOT_RECRUITING
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Diagnostic Odyssey Survey 2 nanCOMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Mitochondrial Dysfunction in Phelan-McDermid Syndrome nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Myotubular Myopathy Genetic Testing Study nanCOMPLETED
Mitochondrial Methylation in Type 2 Diabetes nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
The Natural History of Mitochondrial Diseases nanRECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
mtDNA Mutation Load Analysis in Mesoangioblasts nanRECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis nanUNKNOWN
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
The Crosstalk Between the Epigenome and Mitochondria in SCI nanNOT_YET_RECRUITING
Mitochondrial Dysfunction in Diabetes nanCOMPLETED
Exercise Resistance in Type 2 Diabetes nanACTIVE_NOT_RECRUITING
Natural History Study - Mitochondrial Disease nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a MRM1 binder may also engage these)

ProteinNameSimilarity
Q99J25 — 0.991 Q99J25 →
Q8N9H8 — 0.959 Q8N9H8 →
Q0VC80 — 0.958 Q0VC80 →
Q8BNV1 — 0.958 Q8BNV1 →
Q9JIA7 — 0.957 Q9JIA7 →
Q9DD16 — 0.956 Q9DD16 →
Q2TBK7 — 0.956 Q2TBK7 →
Q9D2Q2 — 0.956 Q9D2Q2 →
Q8VCM2 — 0.955 Q8VCM2 →
Q1JPJ9 — 0.955 Q1JPJ9 →
Q91ZT7 — 0.955 Q91ZT7 →
Q9HC36 — 0.955 Q9HC36 →
Q9JIW4 — 0.955 Q9JIW4 →
Q6P9U1 — 0.954 Q6P9U1 →
E2RD63 — 0.954 E2RD63 →
Q8N2A8 — 0.954 Q8N2A8 →
A8VU90 — 0.954 A8VU90 →
Q8BYR1 — 0.954 Q8BYR1 →
Q6P087 — 0.954 Q6P087 →
Q3UR50 — 0.953 Q3UR50 →
Q2TA57 — 0.953 Q2TA57 →
O35465 — 0.953 O35465 →
Q5ND52 — 0.953 Q5ND52 →
Q6NUI2 — 0.953 Q6NUI2 →
Q3TAA7 — 0.953 Q3TAA7 →
Q8NAG6 — 0.953 Q8NAG6 →
Q9CZB3 — 0.952 Q9CZB3 →
Q60I27 — 0.952 Q60I27 →
Q14296 — 0.952 Q14296 →
Q3U5Q7 — 0.952 Q3U5Q7 →