Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTPRZ1 | P23471 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 3/20 | 0.34 |
| ▸ | KCNK10 | P57789 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21225496 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 | |
| SCHEMBL12828098 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 | |
| SCHEMBL4157946 | 0.80 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 | |
| SCHEMBL16667141 | 0.78 | KCNK2 (0.43) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 | |
| SCHEMBL30410247 | 0.78 | KCNK2 (0.43) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 | |
| SCHEMBL16707555 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 | |
| SCHEMBL900729 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 | |
| SCHEMBL10595472 | 0.76 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1LMNAMAPTTSHR | |
| SCHEMBL10341619 | 0.76 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1TDP1LMNAMAPT | |
| SCHEMBL24616823 | 0.76 | KDM4E (0.52) | SMN1; SMN2ALDH1A1KDM4ETDP1PTPRZ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043191-A1 | PRC2 INHIBITORS FOR USE IN TREATING SICKLE CELL DISEASE | ORIC PHARMACEUTICALS, INC. (US) | 2025-02-27 | — | — | WO | disclosed |
| CN-112004816-B | PRC2 inhibitors | 米拉蒂医疗股份有限公司 | 2024-01-05 | — | — | CN | disclosed |
| WO-2023049723-A1 | PRC2 INHIBITORS FOR USE IN TREATING BLOOD DISORDERS | ORIC PHARMACEUTICALS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |
| CN-114269748-A | Imidazo [1,2-c ] pyrimidine derivatives as PRC2 inhibitors for the treatment of cancer | 米拉蒂医疗股份有限公司 | 2022-04-01 | — | — | CN | disclosed |