Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29528695 | 0.84 | PTGS1 (0.57) | PTGS1PTGS2MAPTCYP1A2CYP3A4 | |
| SCHEMBL29528858 | 0.82 | MAPT (0.61) | PTGS1PTGS2MAPTCYP1A2CYP3A4 | |
| SCHEMBL7573834 | 0.78 | KMT2A (0.47) | PTGS1PTGS2MAPTCYP1A2CYP3A4 | |
| SCHEMBL16039101 | 0.76 | KDM4E (0.60) | MAPTCYP1A2NPC1RAB9AKDM4E | |
| SCHEMBL16104299 | 0.74 | CLK1 (0.55) | TGFBR1PTGS1PTGS2MAPTCYP1A2 | |
| SCHEMBL30845741 | 0.74 | EGLN1 (0.52) | TGFBR1PTGS1PTGS2MAPTCYP1A2 | |
| SCHEMBL8065354 | 0.74 | TGFBR1 (0.50) | TGFBR1PTGS1PTGS2MAPTEGLN1 | |
| SCHEMBL17512464 | 0.74 | TGFBR1 (0.44) | TGFBR1PTGS1PTGS2MAPTCYP1A2 | |
| SCHEMBL174711 | 0.74 | PTGS1 (0.72) | PTGS1PTGS2MAPTCYP1A2CYP3A4 | |
| SCHEMBL3764713 | 0.72 | HRH4 (0.57) | TGFBR1MAPTEGLN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112004816-B | PRC2 inhibitors | 米拉蒂医疗股份有限公司 | 2024-01-05 | — | — | CN | disclosed |
| WO-2023049723-A1 | PRC2 INHIBITORS FOR USE IN TREATING BLOOD DISORDERS | ORIC PHARMACEUTICALS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |
| CN-114269748-A | Imidazo [1,2-c ] pyrimidine derivatives as PRC2 inhibitors for the treatment of cancer | 米拉蒂医疗股份有限公司 | 2022-04-01 | — | — | CN | disclosed |