Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 8/20 | 0.38 |
| ▸ | AOC1 | P19801 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.31 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25321760 | 1.00 | LOXL2 (0.44) | LOXL2AOC3AOC1KCNH2PDE1A | |
| SCHEMBL25320465 | 0.83 | LOXL2 (0.38) | LOXL2AOC3AOC1KCNH2NOS3 | |
| SCHEMBL29529877 | 0.83 | LOXL2 (0.38) | LOXL2AOC3AOC1KCNH2NOS3 | |
| SCHEMBL25319886 | 0.82 | MGAT2 (0.37) | LOXL2AOC3AOC1PDE1APDE1B | |
| SCHEMBL25318386 | 0.78 | LOXL2 (0.46) | LOXL2AOC3AOC1MELK | |
| SCHEMBL29530430 | 0.78 | AOC3 (0.40) | LOXL2AOC3AOC1NOS3NOS1 | |
| SCHEMBL25320177 | 0.78 | AOC3 (0.40) | LOXL2AOC3AOC1NOS3NOS1 | |
| SCHEMBL29102311 | 0.77 | PDE1A (0.38) | AOC3AOC1KCNH2PDE1APDE1B | |
| SCHEMBL25319653 | 0.77 | HTT (0.39) | KCNH2PDE1APDE1BPDE1C | |
| SCHEMBL25318095 | 0.77 | AOC3 (0.44) | LOXL2AOC3AOC1MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217070-A1 | PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Scorpion Therapeutics, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022066734-A1 | PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | SCORPION THERAPEUTICS, INC. (US) | 2022-03-31 | — | — | WO | disclosed |