Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.53 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | FABP6 | P51161 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18863211 | 0.84 | GRM2 (0.50) | PIK3CDPIK3CBPIK3CAGRM2MET | |
| SCHEMBL3532428 | 0.79 | GRM2 (0.46) | PIK3CDPIK3CBPIK3CAGRM2MET | |
| SCHEMBL31159005 | 0.79 | GRM2 (0.46) | PIK3CDPIK3CBPIK3CAGRM2MET | |
| SCHEMBL29662767 | 0.73 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CAPIK3CGKDR | |
| SCHEMBL21349280 | 0.73 | GRM2 (0.41) | PIK3CDPIK3CBPIK3CAGRM2MET | |
| SCHEMBL17141660 | 0.69 | CLK4 (0.46) | PIK3CDPIK3CBPIK3CAGRM2MET | |
| SCHEMBL8169835 | 0.69 | GRM2 (0.44) | PIK3CDPIK3CBPIK3CAGRM2MET | |
| SCHEMBL12240961 | 0.69 | CLK4 (0.44) | PIK3CDPIK3CBPIK3CAGRM2MET | |
| SCHEMBL27085852 | 0.69 | GRM2 (0.44) | PIK3CDPIK3CBPIK3CAGRM2PIK3CG | |
| SCHEMBL6297545 | 0.68 | PARP1 (0.70) | PIK3CDPIK3CBPIK3CAPARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12459921-B2 | Isoindoline compound, preparation method, pharmaceutical composition and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2025-11-04 | — | — | US | disclosed |
| US-20220041576-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2022-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12459921-B2 | Isoindoline compound, preparation method, pharmaceutical composition and use thereof | CUL4B, CUL4A, UBQLN1 | PIK3CD 1078/4885PIK3CB 889/4885PIK3CA 2520/4885 |
| US-20220041576-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | CUL4B, CUL4A, UBQLN1 | PIK3CD 1078/4885PIK3CB 889/4885PIK3CA 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.