Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659580 | 1.00 | BTK (0.51) | BTKLCKGSK3BKDM4EMAPT | |
| SCHEMBL22664846 | 0.91 | BTK (0.51) | BTKLCKGSK3B | |
| Hydrochloric Acid SCHEMBL22659441 | 0.90 | BTK (0.51) | BTKLCKGSK3B | |
| Hydrochloric Acid SCHEMBL29533241 | 0.90 | BTK (0.51) | BTKLCKGSK3B | |
| SCHEMBL22659505 | 0.88 | BTK (0.55) | BTKLCKGSK3BMAPT | |
| SCHEMBL29532936 | 0.88 | BTK (0.55) | BTKLCKGSK3BMAPT | |
| SCHEMBL29533277 | 0.87 | BTK (0.52) | BTKLCKGSK3BPIK3C3CDK9 | |
| SCHEMBL22660078 | 0.87 | BTK (0.52) | BTKLCKGSK3BPIK3C3CDK9 | |
| SCHEMBL22659996 | 0.86 | BTK (0.49) | BTKLCKGSK3BPIK3C3 | |
| SCHEMBL29533390 | 0.86 | BTK (0.49) | BTKLCKGSK3BPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969124-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2022-03-23 | — | — | EP | disclosed |