Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 6/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22659422 | 1.00 | BTK (0.55) | BTKLCKGSK3BMAPK14ABL1 | |
| SCHEMBL29533875 | 0.94 | BTK (0.50) | BTKLCKGSK3BMAPK14 | |
| SCHEMBL22660085 | 0.94 | BTK (0.50) | BTKLCKGSK3BMAPK14 | |
| SCHEMBL22659658 | 0.90 | BTK (0.51) | BTKLCKGSK3BMAPK14ABL1 | |
| SCHEMBL29533977 | 0.90 | BTK (0.51) | BTKLCKGSK3BMAPK14ABL1 | |
| SCHEMBL22659668 | 0.89 | BTK (0.50) | BTKLCKGSK3BMAPK14GSK3A | |
| SCHEMBL22664661 | 0.89 | BTK (0.54) | BTKLCKGSK3BMAPK14 | |
| SCHEMBL29533262 | 0.89 | BTK (0.50) | BTKLCKGSK3BMAPK14GSK3A | |
| Hydrochloric Acid SCHEMBL22659335 | 0.88 | BTK (0.53) | BTKLCKGSK3BMAPK14 | |
| SCHEMBL22659699 | 0.88 | BTK (0.54) | BTKLCKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969124-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2022-03-23 | — | — | EP | disclosed |