Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 9/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21856863 | 1.00 | RXRA (0.48) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL25648717 | 0.85 | RXRA (0.48) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL29509786 | 0.85 | RXRA (0.48) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL21197843 | 0.85 | RXRA (0.48) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL17588934 | 0.85 | RXRA (0.48) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL20439390 | 0.85 | RXRA (0.51) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL23884651 | 0.82 | RXRA (0.47) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL23884443 | 0.82 | RXRA (0.47) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL31512795 | 0.82 | RXRA (0.47) | RXRARXRBRXRGALDH1A1POLB | |
| SCHEMBL30251650 | 0.82 | RXRA (0.47) | RXRARXRBRXRGALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114096542-B | Condensed tricyclic pyrroles as alpha-1 antitrypsin modulators | 弗特克斯药品有限公司 | 2024-09-10 | — | — | CN | disclosed |
| EP-3969440-A1 | CONDENSED TRICYCLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS | Vertex Pharmaceuticals Incorporated (US) | 2022-03-23 | — | — | EP | disclosed |