Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.87 |
| ▸ | LCK | P06239 | 1/20 | 0.76 |
| ▸ | YES1 | P07947 | 1/20 | 0.76 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24734971 | 1.00 | BTK (0.87) | BTKLCKYES1PTK6 | |
| Hydrochloric Acid SCHEMBL29841443 | 0.99 | BTK (0.85) | BTKLCKYES1PTK6 | |
| Hydrochloric Acid SCHEMBL29106909 | 0.99 | BTK (0.85) | BTKLCKYES1PTK6 | |
| SCHEMBL19898376 | 0.93 | BTK (1.00) | BTKLCKYES1PTK6 | |
| SCHEMBL19898447 | 0.92 | BTK (1.00) | BTKLCKYES1PTK6 | |
| SCHEMBL29536127 | 0.92 | BTK (0.77) | BTKLCKYES1PTK6 | |
| SCHEMBL21982163 | 0.92 | BTK (0.88) | BTKLCKYES1PTK6 | |
| SCHEMBL29536186 | 0.90 | BTK (0.74) | BTKLCKYES1PTK6 | |
| SCHEMBL28568486 | 0.90 | BTK (0.74) | BTKLCKYES1PTK6 | |
| SCHEMBL24734958 | 0.90 | BTK (0.79) | BTKLCKYES1PTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117042769-A | Substituted pyrrolopyrimidines and pyrazolopyrimidines as Bruton's Tyrosine Kinase (BTK) degrading agents | 冰洲石生物科技公司 | 2023-11-10 | — | — | CN | disclosed |
| WO-2022169798-A2 | SUBSTITUTED PYRROLOPYRIMIDINE AND PYRAZOLOPYRIMIDINE AS BRUTON'S TYROSINE KINASE (BTK) DEGRADERS | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2022-08-11 | — | — | WO | disclosed |
| CN-112812100-B | Compound capable of degrading BTK kinase, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2022-04-05 | — | — | CN | disclosed |