Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.39 |
| ▸ | AKT2 | P31751 | 11/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25271560 | 1.00 | AKT1 (0.39) | AKT1AKT2CYP1A2FGFR1FLT1 | |
| SCHEMBL25227024 | 0.94 | AKT1 (0.39) | AKT1AKT2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29536669 | 0.94 | AKT1 (0.39) | AKT1AKT2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL25278070 | 0.87 | CYP1A2 (0.40) | AKT1AKT2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29537498 | 0.81 | AKT1 (0.34) | AKT1AKT2HTTALDH1A1 | |
| SCHEMBL25271264 | 0.81 | AKT1 (0.34) | AKT1AKT2HTTALDH1A1 | |
| SCHEMBL25227955 | 0.79 | CDK1 (0.39) | AKT1AKT2CDK1CDK2KDR | |
| SCHEMBL25227902 | 0.79 | CDK1 (0.39) | AKT1AKT2CDK1CDK2KDR | |
| SCHEMBL24271449 | 0.79 | AKT1 (0.34) | AKT1AKT2CYP3A4CYP2D6PRKD3 | |
| SCHEMBL29503634 | 0.79 | AKT1 (0.34) | AKT1AKT2CYP3A4CYP2D6PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710453-A | Kinase inhibitors and uses thereof | 璧辰医药技术股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-4192582-A1 | KINASE INHIBITORS AND USES THEREOF | ABM Therapeutics Corporation (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022032071-A1 | KINASE INHIBITORS AND USES THEREOF | ABM THERAPEUTICS CORPORATION (US) | 2022-02-10 | — | — | WO | disclosed |