Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774832 | 0.83 | MEN1 (0.47) | ALDH1A1GAAHTTHCRTR1SMN1; SMN2 | |
| SCHEMBL294145 | 0.74 | MEN1 (0.44) | ALDH1A1HTTHCRTR1SMN1; SMN2MEN1 | |
| SCHEMBL294455 | 0.72 | ALDH1A1 (0.45) | ALDH1A1GAAHTTSMN1; SMN2MEN1 | |
| SCHEMBL295977 | 0.70 | ALDH1A1 (0.45) | ALDH1A1GAAHTTSMN1; SMN2MEN1 | |
| SCHEMBL17021487 | 0.66 | HCRTR1 (0.53) | ALDH1A1GAAHTTHCRTR1SMN1; SMN2 | |
| SCHEMBL8989531 | 0.66 | ALDH1A1 (0.58) | ALDH1A1GAAHTTSMN1; SMN2MEN1 | |
| SCHEMBL30222894 | 0.66 | ALDH1A1 (0.46) | ALDH1A1GAAHTTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL17028084 | 0.65 | HCRTR1 (0.53) | ALDH1A1GAAHTTHCRTR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17007243 | 0.65 | HCRTR1 (0.53) | ALDH1A1GAAHTTHCRTR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17007244 | 0.65 | HCRTR1 (0.53) | ALDH1A1GAAHTTHCRTR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240474-B1 | CYCLIC PYRIDYL-N-(1,3,4)-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2012-03-14 | — | — | EP | disclosed |
| EP-2240474-A1 | CYCLIC PYRIDYL-N-(1,3,4)-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009080223-A1 | CYCLIC PYRIDYL-N-(1,3,4)-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (FR) | 2009-07-02 | — | — | WO | disclosed |