Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25421713 | 0.92 | MET (0.37) | METKDRMAPK14RAF1MAPK3 | |
| SCHEMBL26074902 | 0.88 | EPHX2 (0.44) | METCDK8 | |
| SCHEMBL29536773 | 0.88 | EPHX2 (0.44) | METCDK8 | |
| SCHEMBL26075414 | 0.87 | AXL (0.37) | METKDRRAF1CDK8 | |
| SCHEMBL26074956 | 0.87 | MET (0.51) | METKDRRETKITPDGFRA | |
| SCHEMBL26075415 | 0.86 | MAPK14 (0.37) | MAPK14 | |
| SCHEMBL29536535 | 0.85 | CDK8 (0.53) | METKDRRAF1CDK8MAPK3 | |
| SCHEMBL25420133 | 0.85 | CDK8 (0.53) | METKDRRAF1CDK8MAPK3 | |
| SCHEMBL29537071 | 0.80 | MAPK14 (0.34) | METKDRMAPK14RETKIT | |
| SCHEMBL25420084 | 0.80 | PDE4B (0.40) | METKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192582-A1 | KINASE INHIBITORS AND USES THEREOF | ABM Therapeutics Corporation (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022032071-A1 | KINASE INHIBITORS AND USES THEREOF | ABM THERAPEUTICS CORPORATION (US) | 2022-02-10 | — | — | WO | disclosed |