Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | VHL | P40337 | 1/20 | 0.37 |
| ▸ | ELOC | Q15369 | 1/20 | 0.37 |
| ▸ | ELOB | Q15370 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15276722 | 1.00 | AAK1 (0.46) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL10226740 | 0.90 | AAK1 (0.45) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL10274517 | 0.90 | AAK1 (0.45) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL13579053 | 0.89 | AAK1 (0.47) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL4549947 | 0.88 | AAK1 (0.49) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL15276604 | 0.86 | AAK1 (0.47) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL10215891 | 0.86 | AAK1 (0.47) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL15401660 | 0.86 | AAK1 (0.47) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL1142034 | 0.86 | AAK1 (0.47) | AAK1USP30PRMT5WDR77BACE1 | |
| SCHEMBL2755130 | 0.86 | AAK1 (0.47) | AAK1USP30PRMT5WDR77BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4221713-A1 | ALLOSTERIC AKT INHIBITORS FOR USE IN THE TREATMENT OF HEREDITARY HEMORRHAGIC TELANGIECTASIA | Vaderis Therapeutics AG (CH) | 2023-08-09 | — | — | EP | disclosed |
| WO-2022069552-A1 | ALLOSTERIC AKT INHIBITORS FOR USE IN THE TREATMENT OF HEREDITARY HEMORRHAGIC TELANGIECTASIA | VADERIS THERAPEUTICS AG (CH) | 2022-04-07 | — | — | WO | disclosed |