Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.55 |
| ▸ | THRB | P10828 | 4/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.40 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295392 | 1.00 | THRA (0.55) | THRATHRBS1PR1S1PR3S1PR4 | |
| Hydrochloric Acid SCHEMBL295255 | 0.99 | THRA (0.54) | THRATHRBS1PR1S1PR3S1PR4 | |
| Hydrochloric Acid SCHEMBL295254 | 0.99 | THRA (0.54) | THRATHRBS1PR1S1PR3S1PR4 | |
| SCHEMBL295364 | 0.93 | THRA (0.48) | THRATHRBS1PR1S1PR3S1PR4 | |
| SCHEMBL295363 | 0.93 | THRA (0.48) | THRATHRBS1PR1S1PR3S1PR4 | |
| SCHEMBL294681 | 0.87 | SMN1; SMN2 (0.46) | THRATHRBS1PR1S1PR3S1PR4 | |
| SCHEMBL294682 | 0.87 | SMN1; SMN2 (0.46) | THRATHRBS1PR1S1PR3S1PR4 | |
| SCHEMBL365503 | 0.85 | S1PR1 (0.45) | THRATHRBS1PR1S1PR3S1PR4 | |
| SCHEMBL294540 | 0.82 | SMN1; SMN2 (0.42) | THRATHRBS1PR1S1PR3S1PR4 | |
| SCHEMBL294539 | 0.82 | SMN1; SMN2 (0.42) | THRATHRBS1PR1S1PR3S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636171-B1 | AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | claimed |