Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.65 |
| ▸ | KDM1A | O60341 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 6/20 | 0.62 |
| ▸ | KDR | P35968 | 6/20 | 0.62 |
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.59 |
| ▸ | STK17B | O94768 | 1/20 | 0.59 |
| ▸ | STK10 | O94804 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422710 | 1.00 | SRC (0.65) | SRCKDM1AKDM4EAURKAEGFR | |
| SCHEMBL4428694 | 1.00 | SRC (0.65) | SRCKDM1AKDM4EAURKAEGFR | |
| SCHEMBL4417717 | 0.94 | KDR (0.61) | SRCKDM1AKDM4EAURKAEGFR | |
| SCHEMBL31491127 | 0.90 | SRC (0.53) | SRCKDM1AKDM4EAURKAEGFR | |
| SCHEMBL4426202 | 0.90 | EHMT2 (0.70) | SRCEGFRKDRAXLFLT4 | |
| SCHEMBL4431962 | 0.89 | EHMT2 (0.69) | EGFRKDRFLT4ABCB11RET | |
| SCHEMBL4423943 | 0.89 | EHMT2 (0.59) | KDM1AAURKAEGFRKDRFLT4 | |
| SCHEMBL4430442 | 0.89 | EHMT2 (0.69) | EGFRKDRFLT4ABCB11RET | |
| SCHEMBL25281864 | 0.88 | SRC (0.66) | SRCKDM1AKDM4EAURKAEGFR | |
| SCHEMBL5495221 | 0.88 | SRC (0.66) | SRCKDM1AKDM4EAURKAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281078-A1 | PHARMACEUTICAL COMBINATIONS OF SOS1 INHIBITORS FOR TREATING AND/OR PREVENTING CANCER | Lupin Limited (IN) | 2023-11-29 | — | — | EP | disclosed |
| CN-115403557-A | Quinoline and quinazoline compounds as fourth-generation EGFR (epidermal growth factor receptor) inhibitor and application thereof | 华东理工大学 | 2022-11-29 | — | — | CN | disclosed |
| WO-2022157629-A1 | PHARMACEUTICAL COMBINATIONS OF SOS1 INHIBITORS FOR TREATING AND/OR PREVENTING CANCER | LUPIN LIMITED (IN) | 2022-07-28 | — | — | WO | disclosed |
| CN-110418789-B | Derivatives of N-cycloalkyl/heterocycloalkyl-4- (imidazo [1,2-a ] pyridine) pyrimidin-2-amines as therapeutic agents | 常州千红生化制药股份有限公司 | 2022-03-25 | — | — | CN | disclosed |