Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 8/20 | 0.70 |
| ▸ | EHMT1 | Q9H9B1 | 8/20 | 0.70 |
| ▸ | SPIN1 | Q9Y657 | 4/20 | 0.63 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.62 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | FLT4 | P35916 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | ERN1 | O75460 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430442 | 0.99 | EHMT2 (0.69) | EHMT2EHMT1SPIN1TLR9TLR7 | |
| SCHEMBL4431962 | 0.99 | EHMT2 (0.69) | EHMT2EHMT1SPIN1TLR9TLR7 | |
| SCHEMBL4419423 | 0.94 | EHMT2 (0.61) | EHMT2EHMT1SPIN1TLR9TLR7 | |
| SCHEMBL4431419 | 0.94 | EHMT2 (0.61) | EHMT2EHMT1SPIN1TLR9TLR7 | |
| SCHEMBL4427357 | 0.93 | EHMT2 (0.60) | EHMT2EHMT1SPIN1TLR9TLR7 | |
| SCHEMBL4423943 | 0.92 | EHMT2 (0.59) | EHMT2EHMT1SPIN1TLR9TLR7 | |
| SCHEMBL4428694 | 0.90 | SRC (0.65) | KITKDREGFRFGFR1FLT1 | |
| SCHEMBL4422710 | 0.90 | SRC (0.65) | KITKDREGFRFGFR1FLT1 | |
| SCHEMBL29540227 | 0.90 | SRC (0.65) | KITKDREGFRFGFR1FLT1 | |
| SCHEMBL4426096 | 0.88 | RET (0.59) | EHMT2EHMT1SPIN1TLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313975-A1 | SMALL MOLECULES FOR THE TREATMENT OF KINASE-RELATED DISEASES | Athos Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-115485372-A | Host defense suppression methods and compositions for regulating genomes | 旗舰先锋创新VI有限责任公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2022204683-A1 | SMALL MOLECULES FOR THE TREATMENT OF KINASE-RELATED DISEASES | ATHOS THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |
| US-7498335-B2 | Method of producing an antiangiogenic or vascular permeability reducing effect | ASTRAZENECA AB (CH) | 2009-03-03 | — | — | US | disclosed |
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007054357-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2007-05-18 | — | — | WO | disclosed |
| EP-1785420-A1 | Thiazole analogues and uses thereof | 4SC AG (DE) | 2007-05-16 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1272185-B1 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |
| US-20030225111-A1 | Therapy | ASTRAZENECA AB (SE) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225111-A1 | Therapy | VEGFA, AQP1, FLT1 | EHMT2 3260/4885EHMT1 1608/4885SPIN1 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.