Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 3/20 | 0.59 |
| ▸ | PIM1 | P11309 | 3/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 3/20 | 0.59 |
| ▸ | AKT1 | P31749 | 3/20 | 0.59 |
| ▸ | AKT2 | P31751 | 3/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.59 |
| ▸ | NEK2 | P51955 | 3/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.59 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.59 |
| ▸ | STK3 | Q13188 | 3/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334525 | 1.00 | CHEK1 (0.59) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| Hydrochloric Acid SCHEMBL2274914 | 0.99 | CHEK1 (0.58) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| Hydrochloric Acid SCHEMBL5974249 | 0.99 | CHEK1 (0.58) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| Hydrochloric Acid SCHEMBL5974369 | 0.99 | CHEK1 (0.58) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| Hydrochloric Acid SCHEMBL5974644 | 0.99 | CHEK1 (0.58) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| Hydrochloric Acid SCHEMBL5975382 | 0.99 | CHEK1 (0.58) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| SCHEMBL6329737 | 0.99 | CHEK1 (0.60) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| Hydrochloric Acid SCHEMBL5973967 | 0.98 | CHEK1 (0.59) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| SCHEMBL6326351 | 0.96 | CHEK1 (0.60) | CHEK1DAPK3ROCK2CHEK2CDK1 | |
| Hydrochloric Acid SCHEMBL5974367 | 0.95 | CHEK1 (0.59) | CHEK1DAPK3ROCK2CHEK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0963197-B1 | GUANYLHYDRAZONES USEFUL FOR TREATING DISEASES ASSOCIATED WITH T CELL ACTIVATION | CYTOKINE PHARMASCIENCES INC (US) | 2010-01-06 | — | — | EP | claimed |
| US-5854289-A | Guanylhydrazones and their use to treat inflammatory conditions | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 1998-12-29 | — | — | US | claimed |
| EP-1255541-B1 | AROMATIC GUANYLHYDRAZONE FOR THE TREATMENT OF RESISTANT VIRAL INFECTIONS | BEVEC DORIAN (DE) | 2005-11-09 | — | — | EP | disclosed |
| US-20050171176-A1 | Pharmaceutically active aromatic guanylhydrazones | BEVEC DORIAN (DE) | 2005-08-04 | — | — | US | disclosed |
| US-20030203969-A1 | Pharmaceutically active aromatic guanylhydrazones | AXXIMA PHARMACEUTICALS AG (DE) | 2003-10-30 | — | — | US | disclosed |
| EP-1255541-A2 | PHARMACEUTICALLY ACTIVE AROMATIC GUANYLHYDRAZONES | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056553-A2 | PHARMACEUTICALLY ACTIVE AROMATIC GUANYLHYDRAZONES | AXXIMA PHARMACEUTICALS AG (DE) | 2001-08-09 | — | — | WO | disclosed |
| US-5859062-A | ADMINISTERING TO TREAT INFLAMMATORY DISEASES MEDIATED BY TUMOR NECROSIS FACTOR | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 1999-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203969-A1 | Pharmaceutically active aromatic guanylhydrazones | DHPS, GGPS1, GMPS | CHEK1 4752/4885DAPK3 996/4885ROCK2 2908/4885 |
| US-20050171176-A1 | Pharmaceutically active aromatic guanylhydrazones | DHPS, GGPS1, GMPS | CHEK1 4743/4885DAPK3 1031/4885ROCK2 2934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.