Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172244 | 1.00 | MAPK1 (0.49) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL28300532 | 0.78 | MAPK1 (0.50) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL4240540 | 0.77 | MAPK1 (0.49) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL2592400 | 0.77 | MAPK1 (0.49) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL4341886 | 0.77 | MAPK1 (0.67) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL18338833 | 0.77 | MAPK1 (0.45) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL26342753 | 0.77 | NPC1 (0.45) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL29417843 | 0.76 | MAPK1 (0.56) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL2454736 | 0.76 | MAPK1 (0.56) | MAPK1NPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL10262373 | 0.76 | MAPK1 (0.47) | MAPK1NPC1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214197-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | Nura Bio, Inc. (US) | 2023-07-26 | — | — | EP | disclosed |
| WO-2022060812-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. (US) | 2022-03-24 | — | — | WO | disclosed |