Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | TLR4 | O00206 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17905717 | 0.84 | CHRNB2 (0.68) | CHRNB2CHRNA4TLR4TLR2HPGD | |
| SCHEMBL7643659 | 0.83 | CHRNB2 (0.60) | CHRNB2CHRNA4HPGDLMNAMAPT | |
| SCHEMBL8461839 | 0.83 | CHRNB2 (0.67) | CHRNB2CHRNA4TLR4TLR2HPGD | |
| SCHEMBL9795553 | 0.82 | CHRNB2 (0.65) | CHRNB2CHRNA4TLR4TLR2HPGD | |
| SCHEMBL9172223 | 0.82 | CHRNB2 (0.65) | CHRNB2CHRNA4TLR4TLR2HPGD | |
| SCHEMBL5973196 | 0.82 | CHRNB2 (0.65) | CHRNB2CHRNA4TLR4TLR2HPGD | |
| SCHEMBL2374109 | 0.80 | CHRNB2 (0.70) | CHRNB2CHRNA4TLR4TLR2HPGD | |
| SCHEMBL15498199 | 0.80 | CHRNB2 (0.73) | CHRNB2CHRNA4HPGDLMNAMAPT | |
| SCHEMBL8472550 | 0.79 | CHRNB2 (0.58) | CHRNB2CHRNA4HPGDLMNAMAPT | |
| SCHEMBL7042749 | 0.77 | CHRNB2 (0.67) | CHRNB2CHRNA4TLR4TLR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086892-A1 | INTERLEUKIN 4 (IL4)-INDUCED GENE 1 INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2022-04-28 | — | — | WO | disclosed |