Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3194072 | 0.80 | HDAC4 (0.44) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL3957685 | 0.77 | NPC1 (0.44) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL31024085 | 0.77 | NPC1 (0.47) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL31024054 | 0.70 | KDM4E (0.43) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL10387595 | 0.69 | SLC18A3 (0.42) | DRD2TDP1KDM4E | |
| SCHEMBL30977435 | 0.68 | HDAC4 (0.39) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL14403054 | 0.66 | ESR2 (0.44) | DRD2POLB | |
| SCHEMBL1941324 | 0.64 | TP53 (0.47) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL8607901 | 0.62 | HTR2C (0.38) | TP53 | |
| SCHEMBL2859850 | 0.62 | HTR2C (0.38) | DRD4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022070288-A1 | NITROGEN-CONTAINING BICYCLIC COMPOUND | 旭化成ファーマ株式会社 | 2022-04-07 | — | — | WO | disclosed |