Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 11/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | GAA | P10253 | 8/20 | 0.42 |
| ▸ | GFER | P55789 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013794 | 1.00 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL12946054 | 0.89 | MAPK13 (0.47) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL15638942 | 0.86 | HDAC1 (0.42) | MAPTKDM4EMEN1KMT2AGAA | |
| SCHEMBL11400584 | 0.82 | MAPK13 (0.49) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL11468680 | 0.82 | KDM4E (0.56) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL952942 | 0.81 | MAPT (0.59) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL29330480 | 0.81 | MAPT (0.50) | MAPK14MAPTKDM4EMEN1KMT2A | |
| SCHEMBL31402919 | 0.79 | GAA (0.53) | MAPK14MAPTKDM4EMEN1KMT2A | |
| SCHEMBL25250382 | 0.78 | KDM4E (0.62) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL27728400 | 0.78 | MAPK13 (0.41) | MAPK14MAPK13MAPK12MAPK11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986885-A1 | SUBSTITUTED PYRROLIDINE AMIDES IV | Grünenthal GmbH (DE) | 2022-04-27 | — | — | EP | disclosed |