Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 13/20 | 0.80 |
| ▸ | CHRNA4 | P43681 | 13/20 | 0.80 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2956250 | 1.00 | CHRNB2 (0.80) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL5986465 | 1.00 | CHRNB2 (0.80) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL3046728 | 1.00 | CHRNB2 (0.80) | CHRNB2CHRNA4CHRNB4CHRNA3HRH4 | |
| SCHEMBL2962585 | 0.91 | CHRNB2 (0.84) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2958303 | 0.91 | CHRNB2 (0.84) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2962145 | 0.91 | CHRNB2 (0.84) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5988489 | 0.91 | CHRNB2 (0.84) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5367436 | 0.89 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7689605 | 0.89 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2949362 | 0.88 | CHRNB2 (0.74) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41439-E1 | Pharmaceutical compositions and methods for use | TARGACEPT, INC. (US) | 2010-07-13 | — | — | US | disclosed |