Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552269 | 0.78 | TYK2 (0.51) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL28358935 | 0.77 | TYK2 (0.61) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL29922615 | 0.77 | TYK2 (0.50) | MAPTJAK2TYK2JAK1JAK3 | |
| SCHEMBL28358938 | 0.77 | TYK2 (0.50) | MAPTJAK2TYK2JAK1JAK3 | |
| SCHEMBL29922505 | 0.72 | JAK2 (0.46) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL29552914 | 0.72 | TYK2 (0.48) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL13589532 | 0.72 | MAPT (0.54) | MAPTKDM4EMEN1KMT2AGAA | |
| SCHEMBL24746327 | 0.70 | TYK2 (0.43) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL30316376 | 0.70 | TYK2 (0.43) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL28883611 | 0.65 | JAK2 (0.59) | JAK2TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |