Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.48 |
| ▸ | JAK2 | O60674 | 7/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 2/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359094 | 0.81 | TYK2 (0.74) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29552977 | 0.73 | CTSC (0.41) | TYK2JAK2JAK1JAK3CTSC | |
| SCHEMBL29552080 | 0.72 | MAPT (0.42) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL29552531 | 0.70 | JAK2 (0.43) | TYK2JAK2JAK1JAK3WEE1 | |
| SCHEMBL29551980 | 0.68 | TYK2 (0.57) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28362685 | 0.68 | TYK2 (0.57) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL5158713 | 0.68 | SLC6A2 (0.37) | TYK2JAK2JAK1JAK3FLT3 | |
| SCHEMBL4898764 | 0.68 | CDK4 (0.39) | TYK2FLT3WEE1CCNT1CDK4 | |
| SCHEMBL1393493 | 0.67 | BTK (0.40) | FLT3CCNT1CDK4CCND1CCND3 | |
| SCHEMBL29551761 | 0.67 | TYK2 (0.57) | TYK2JAK2JAK1JAK3WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |