Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.51 |
| ▸ | TYK2 | P29597 | 7/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | UGCG | Q16739 | 2/20 | 0.37 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362689 | 0.92 | JAK2 (0.51) | JAK2TYK2JAK1JAK3MKNK1 | |
| SCHEMBL29922891 | 0.91 | JAK2 (0.50) | JAK2TYK2JAK1JAK3MKNK1 | |
| SCHEMBL29551757 | 0.91 | JAK2 (0.50) | JAK2TYK2JAK1JAK3MKNK1 | |
| SCHEMBL28358949 | 0.91 | JAK2 (0.50) | JAK2TYK2JAK1JAK3MKNK1 | |
| SCHEMBL29551936 | 0.81 | MKNK1 (0.44) | JAK2MKNK1KITFLT3PIK3CA | |
| SCHEMBL28358955 | 0.76 | JAK2 (0.57) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29551959 | 0.74 | JAK2 (0.46) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29552149 | 0.73 | TYK2 (0.46) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29552473 | 0.73 | JAK2 (0.44) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29552441 | 0.72 | JAK2 (0.48) | JAK2TYK2JAK1JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |