Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.54 |
| ▸ | JAK1 | P23458 | 6/20 | 0.54 |
| ▸ | TYK2 | P29597 | 6/20 | 0.54 |
| ▸ | JAK3 | P52333 | 6/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359124 | 0.91 | JAK2 (0.66) | JAK2JAK1TYK2JAK3CCNB2 | |
| SCHEMBL29552137 | 0.91 | JAK2 (0.54) | JAK2JAK1TYK2JAK3CCNB2 | |
| SCHEMBL28359246 | 0.91 | JAK2 (0.54) | JAK2JAK1TYK2JAK3CCNB2 | |
| SCHEMBL29552110 | 0.85 | JAK2 (0.55) | JAK2JAK1TYK2JAK3CCNB2 | |
| SCHEMBL28883611 | 0.83 | JAK2 (0.59) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29551766 | 0.81 | JAK2 (0.51) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL29552228 | 0.80 | TYK2 (0.61) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL29551995 | 0.80 | JAK2 (0.69) | JAK2JAK1TYK2JAK3CCNB2 | |
| SCHEMBL28359167 | 0.80 | JAK2 (0.69) | JAK2JAK1TYK2JAK3CCNB2 | |
| SCHEMBL29552269 | 0.79 | TYK2 (0.51) | JAK2JAK1TYK2JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |