Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362552 | 1.00 | JAK2 (0.40) | JAK2JAK3JAK1TYK2ROCK2 | |
| SCHEMBL29922752 | 0.91 | JAK2 (0.49) | JAK2JAK3JAK1TYK2ROCK2 | |
| SCHEMBL29552283 | 0.91 | JAK2 (0.49) | JAK2JAK3JAK1TYK2ROCK2 | |
| SCHEMBL28359058 | 0.91 | JAK2 (0.49) | JAK2JAK3JAK1TYK2ROCK2 | |
| SCHEMBL29551804 | 0.88 | JAK2 (0.42) | JAK2JAK3JAK1TYK2MAPK14 | |
| SCHEMBL28358866 | 0.84 | JAK2 (0.40) | JAK2JAK3JAK1TYK2PTK2 | |
| SCHEMBL29922644 | 0.83 | HDAC1 (0.43) | JAK2JAK3ROCK2HDAC1PIK3CA | |
| SCHEMBL28362559 | 0.83 | HDAC1 (0.43) | JAK2JAK3ROCK2HDAC1PIK3CA | |
| SCHEMBL29552248 | 0.80 | ABCB1 (0.41) | JAK2JAK3JAK1TYK2NPC1 | |
| SCHEMBL29922466 | 0.80 | ABCB1 (0.41) | JAK2JAK3JAK1TYK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |