Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362559 | 1.00 | HDAC1 (0.43) | HDAC1ESR2PIK3CAMTORROCK2 | |
| SCHEMBL29551964 | 0.87 | SYK (0.40) | MAPTNAMPTSYKMEN1KMT2A | |
| SCHEMBL28362552 | 0.83 | JAK2 (0.40) | HDAC1ESR2PIK3CAMTORROCK2 | |
| SCHEMBL29552783 | 0.83 | JAK2 (0.40) | HDAC1ESR2PIK3CAMTORROCK2 | |
| SCHEMBL28359226 | 0.82 | GPR119 (0.40) | HDAC1NPC1RAB9AKMT2A | |
| SCHEMBL28362546 | 0.78 | SYK (0.43) | MAPTSYKMEN1KMT2A | |
| SCHEMBL29922602 | 0.78 | SYK (0.43) | MAPTSYKMEN1KMT2A | |
| SCHEMBL29551791 | 0.75 | SYK (0.41) | MAPTSYKKMT2A | |
| SCHEMBL28362756 | 0.75 | ABCB1 (0.45) | NPC1RAB9AMAPTSYKMEN1 | |
| SCHEMBL29551921 | 0.75 | ABCB1 (0.45) | NPC1RAB9AMAPTSYKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |