Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 5/20 | 0.38 |
| ▸ | Q9HBH1 | 1/20 | 0.35 | |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | FURIN | P09958 | 7/20 | 0.32 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12436525 | 0.88 | FAP (0.44) | FAPPDFALDH1A1L3MBTL1FURIN | |
| SCHEMBL17178689 | 0.88 | FAP (0.44) | FAPPDFALDH1A1L3MBTL1FURIN | |
| SCHEMBL12441917 | 0.88 | FAP (0.44) | FAPPDFALDH1A1L3MBTL1FURIN | |
| SCHEMBL3798438 | 0.88 | FAP (0.44) | FAPPDFALDH1A1L3MBTL1FURIN | |
| SCHEMBL18391329 | 0.88 | FAP (0.44) | FAPPDFALDH1A1L3MBTL1FURIN | |
| SCHEMBL3205376 | 0.88 | FAP (0.44) | FAPPDFALDH1A1L3MBTL1FURIN | |
| SCHEMBL12442419 | 0.88 | FAP (0.44) | FAPPDFALDH1A1L3MBTL1FURIN | |
| Water SCHEMBL30811226 | 0.87 | FAP (0.43) | FAPPDFALDH1A1L3MBTL1FURIN | |
| SCHEMBL31468833 | 0.86 | FAP (0.42) | FAPFURINSIRT2 | |
| SCHEMBL12435192 | 0.85 | FAP (0.38) | FAPPDFFURINSSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999501-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | Silverback Therapeutics, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |