Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604688 | 0.84 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL12604691 | 0.84 | NR1H2 (0.41) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL12550669 | 0.83 | NR1H2 (0.40) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL17122072 | 0.80 | USP2 (0.43) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL17190705 | 0.80 | USP2 (0.43) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL27038748 | 0.79 | NR1H2 (0.45) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL15401504 | 0.78 | CHRM2 (0.46) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL17122067 | 0.78 | USP2 (0.44) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL27038481 | 0.76 | USP2 (0.47) | NR1H2USP2SMN1; SMN2HPGDRECQL | |
| SCHEMBL27038646 | 0.75 | MEN1 (0.40) | NR1H2USP2SMN1; SMN2HPGDRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240352-A1 | T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF | Praxis Precision Medicines, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099207-A1 | T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2022-05-12 | — | — | WO | disclosed |