Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lumateperone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 18/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 1.00 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.83 |
| ▸ | HTR2C | P28335 | 15/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | DRD4 | P21917 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 1/20 | 1.00 |
| ▸ | CCR3 | P51677 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lumateperone SCHEMBL29355976 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL1769664 | 1.00 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL22635597 | 0.96 | HTR2A (0.91) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL31465557 | 0.96 | HTR2A (0.91) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL21996433 | 0.94 | HTR2A (0.88) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL31032326 | 0.94 | HTR2A (0.88) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL16005572 | 0.91 | HTR2A (0.90) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL22067597 | 0.91 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL21524899 | 0.91 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR1ADRD1 | |
| Lumateperone SCHEMBL17681371 | 0.91 | HTR2A (1.00) | HTR2AHTR2CSLC6A4HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230382914-A1 | SOLID STATE FORMS OF LUMATEPERONE DITOSYLATE SALT | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2023-11-30 | — | — | US | disclosed |
| US-11760757-B2 | Solid state forms of lumateperone ditosylate salt | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2023-09-19 | — | — | US | disclosed |
| EP-4001281-A1 | SOLID STATE FORMS OF LUMATEPERONE DITOSYLATE SALT AND PREPARATION THEREOF | Teva Pharmaceuticals International GmbH (CH) | 2022-05-25 | — | — | EP | disclosed |
| US-11332469-B2 | Solid state forms of lumateperone ditosylate salt | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2022-05-17 | — | — | US | disclosed |
| US-20220127268-A1 | SOLID STATE FORMS OF LUMATEPERONE DITOSYLATE SALT | ASSIA CHEMICAL INDUSTRIES LTD. (IL) | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760757-B2 | Solid state forms of lumateperone ditosylate salt | LSS, DHPS, LPXN | HTR2A 1890/4885SLC6A4 215/4885DRD2 1115/4885 |
| US-20220127268-A1 | SOLID STATE FORMS OF LUMATEPERONE DITOSYLATE SALT | LSS, DHPS, LPXN | HTR2A 1890/4885SLC6A4 215/4885DRD2 1115/4885 |
| US-11332469-B2 | Solid state forms of lumateperone ditosylate salt | LSS, DHPS, LPXN | HTR2A 1890/4885SLC6A4 215/4885DRD2 1115/4885 |
| US-20230382914-A1 | SOLID STATE FORMS OF LUMATEPERONE DITOSYLATE SALT | LSS, DHPS, LPXN | HTR2A 1890/4885SLC6A4 215/4885DRD2 1115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.