Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21541831 | 1.00 | SYK (0.37) | SYKMETPDE3BPDE3APIK3CA | |
| SCHEMBL21541815 | 0.91 | SYK (0.38) | SYKMETPDE3BPDE3APIK3CA | |
| SCHEMBL21541752 | 0.90 | SYK (0.36) | SYKMETPDE3BPDE3APIK3CA | |
| SCHEMBL21541800 | 0.88 | MELK (0.35) | SYKMETPDE3BPDE3APIK3CA | |
| SCHEMBL21541761 | 0.88 | KCNH2 (0.37) | SYKMETPDE3BPDE3APIK3CA | |
| SCHEMBL21541749 | 0.87 | CSF1R (0.37) | METPDE3BPDE3APIK3CACDK4 | |
| SCHEMBL29558902 | 0.86 | CDK4 (0.35) | METPDE3BPDE3APIK3CACDK4 | |
| SCHEMBL21541779 | 0.86 | CDK4 (0.35) | METPDE3BPDE3APIK3CACDK4 | |
| SCHEMBL21541861 | 0.84 | PRKDC (0.44) | METPDE3BPDE3APIK3CAATM | |
| SCHEMBL21541723 | 0.83 | MELK (0.35) | METPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567041-A9 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-04-20 | — | — | EP | disclosed |