Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vonoprazan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vonoprazan SCHEMBL28725455 | 1.00 | GAA (0.39) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL29407860 | 0.99 | GAA (0.40) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL29419681 | 0.99 | GAA (0.40) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL194487 | 0.99 | GAA (0.40) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL29419683 | 0.99 | GAA (0.40) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL194396 | 0.92 | CHRNB2 (0.39) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL31647237 | 0.92 | CHRNB2 (0.39) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL29407867 | 0.92 | CHRNB2 (0.39) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL29379818 | 0.92 | CHRNB2 (0.39) | GAAKMT2ACHRNB2CHRNB4CHRNA3 | |
| Vonoprazan SCHEMBL194394 | 0.92 | CHRNB2 (0.39) | GAAKMT2ACHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107778286-B | Synthesis process of voronoi fumarate | 四川弘远药业有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-117069695-A | Potassium ion competitive acid retarder solid free form and preparation method thereof | 南京道尔医药研究院有限公司 | 2023-11-17 | — | — | CN | claimed |
| CN-107778286-B | Synthesis process of voronoi fumarate | 四川弘远药业有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-107778286-B | Synthesis process of voronoi fumarate | 四川弘远药业有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117069695-B | Potassium ion competitive acid retarder solid free form and preparation method thereof | 南京道尔医药研究院有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-117069695-A | Potassium ion competitive acid retarder solid free form and preparation method thereof | 南京道尔医药研究院有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-114380796-A | Preparation method of vonoprazan fumarate | 杭州中美华东制药有限公司 | 2022-04-22 | — | — | CN | disclosed |