Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198594 | 1.00 | HDAC1 (0.39) | HDAC1HDAC6ADORA2ATRPV1PIN1 | |
| SCHEMBL3312236 | 0.91 | HDAC1 (0.46) | HDAC1HDAC6ADORA2AP2RX7 | |
| SCHEMBL30558705 | 0.91 | HDAC1 (0.46) | HDAC1HDAC6ADORA2AP2RX7 | |
| SCHEMBL11983384 | 0.83 | FNTA (0.40) | HDAC1HDAC6TRPV1P2RX7FNTA | |
| SCHEMBL26118246 | 0.82 | P2RX7 (0.38) | HDAC1HDAC6ADORA2ATRPV1P2RX7 | |
| SCHEMBL30557077 | 0.81 | P2RX7 (0.39) | PIN1P2RX7FNTAFNTBIDH1 | |
| SCHEMBL26120675 | 0.81 | P2RX7 (0.39) | PIN1P2RX7FNTAFNTBIDH1 | |
| SCHEMBL1155880 | 0.81 | OPRL1 (0.40) | HDAC1HDAC6TRPV1PIN1P2RX7 | |
| SCHEMBL30556783 | 0.80 | ADORA2A (0.37) | HDAC1HDAC6ADORA2ATRPV1P2RX7 | |
| SCHEMBL26123314 | 0.80 | ADORA2A (0.37) | HDAC1HDAC6ADORA2ATRPV1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |